3.10 Eye diseases

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3.10.1 Cataract

Cataract is a leading cause of vision loss and blindness in Australia.28 The ocular lens, which focuses light on to the retina, is normally a transparent organ. With age it has a tendency to develop opaque areas, and when the opacity begins to impair vision, it is called a cataract. There are three main types of cataract, known as nuclear, cortical and posterior subcapsular lens opacity, each with its own distinct risk factors.5 Smoking is a cause of nuclear cataract, which occurs in the centre of the lens. Although the exact mechanism for causation is not known, many trace metals and other chemicals in cigarette smoke are capable of damaging lens proteins. Quitting smoking may reduce the risk of developing nuclear opacity.5

Smoking may also be associated with an increased risk for developing posterior subcapsular opacity (a cataract situated under the external membrane, usually behind the lens) but more research is required.5

3.10.2 Age-related macular degeneration

Age-related macular degeneration (AMD) is also a major cause of vision impairment and blindness in Australia.28 The macula is the central area of the retina, and is responsible for high-resolution vision. Studies are increasingly identifying smoking as a major risk factor for developing AMD.64, 65

3.10.3 Graves' ophthalmopathy

Graves' ophthalmopathy is a complication of Graves' disease, a fairly rare thyroid disease. The eye complications include protrusion of the eyeballs, double vision, inflammation of eye tissue and damage to the optic nerve. A number of studies have observed an increased risk among smokers for developing the ocular complications of Graves' disease. At this stage the evidence is not conclusive, and further research is required.5

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