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18.5.5 Chemicals in e-cigarettes sold in Australia
Foreword

Relevant news and research: Chemicals in e-cigarettes sold in Australia

Turner, A., Scott, J. W. and Dabrowski, M. C. (2026). Aluminium, copper, nickel, lead and zinc in e-liquids from contemporary disposable vapes. Environ Monit Assess, 4. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41872591


Wong, M., Martinez, T., Hua, M., Hendricks, N. G. and Talbot, P. (2026). Unraveling the Toxicological Effects of Hydroxyacetone horizontal line A Reaction Product in Electronic Cigarette Aerosols. Chem Res Toxicol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41650339


Canchola, A., Chen, K., Rahman, M. Z., Tran, L., Woo, W., Tian, L., Lin, Y. H. and Chou, W. C. (2026). Developing a multi-task quantitative structure-activity relationship (QSAR) model for predicting the toxicity potential of chemicals used in e-cigarette products. J Hazard Mater, 141164. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41570531


Miguel, R. T. D., Ali, R. and El Joumaa, M. (2025). Tobacco-specific nitrosamine exposure from electronic cigarettes versus combustible cigarettes: an ad hoc analysis within a systematic review of emission studies. Front Oncol, 1729107. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41458601


Sun, Y., Kaur, G., Effah, F., Friedman, A. and Rahman, I. (2025). Cytotoxic and oxidative effects of commercially available propylene glycol (PG) and vegetable glycerin (VG): Common humectants in electronic cigarettes. Toxicol Rep, 102171. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41377029


Taylor, E., Robson, D., Brose, L. S., Hammond, D., Reid, J. L., Block, A. C., Goniewicz, M. L., Nikolaidou, M. and McNeill, A. (2025). Nicotine and tobacco-specific nitrosamine exposure among youth in England who smoke cigarettes and/or vape. Tob Control. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41344996


Woo, W., Tian, L., Diamond, C., Lum, M., Lyons, T. and Lin, Y. H. (2026). Interplay of Metals and Organics in E-Cigarette Aerosols Enhances the Production of Reactive Oxygen Species within Ultrafine Particles: Implications for Passive Vaping Exposures. Environ Sci Technol, 1, 949-958. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41467792


Alam El Din, S. M., Iyengar, S., Aherrera, A. D., Quarles, C. D., Jr., Mihalic, J., Bressler, J. and Rule, A. M. (2025). Detection of Metal-Containing Particles in FDA-Authorized and New Disposable Electronic Cigarette Aerosols. Environ Sci Technol, 46, 24707-24716. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41247037


Fragoso, C. L. R., De Falco, A., Santa-Helena, E., Gioda, C. R. and Gioda, A. (2026). Toxicological evaluation of vape liquids circulating in Brazil: Evidence of emerging hazards. Toxicology, 154326. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41175964


Khatun, J. and Dhak, D. (2025). Emerging acrolein: a pulmonary and cardiac hazard and its association with cigarette, and e-cigarettes. Chem Biol Interact, 111794. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41177258


Sun, Y., Lin, K., Effah, F., Cartujano Barrera, F., Li, D., McIntosh, S., McGraw, M. D. and Rahman, I. (2025). Toxicity of humectants propylene glycol and vegetable glycerin in electronic nicotine delivery systems. Toxicol Lett, 111739. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41043656


Wong, M., Martinez, T., Hendricks, N. and Talbot, P. (2025). Acetaldehyde and methylglyoxal: comparative analysis of toxic electronic cigarette degradation products in 3D and 2D exposure systems using human bronchial epithelial models. Front Toxicol, 1624794. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41098480


Dong, Z., Pang, Q., Ling, Q., He, C., Wu, G., Wei, S., Deng, W., Liu, C., Qian, J., Fu, Y., Hai, T., Chen, Z., Yun, L. and Rong, X. (2025). Heating Coil Corrosion by E-Liquid Containing Nicotine Lactate Salt and In Vitro and In Vivo Evaluation of Nickel Leachate in E-Liquid and E-Cigarette Aerosol. Chem Res Toxicol, 9, 1557-1563. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40907005


Gajdosechova, Z., Marleau-Gillette, J., Polivchuk, M., Kosarac, I., Katuri, G. P., Das, D., Cabecinha, A., Waye, A. and Abramovici, H. (2025). Tracking metal presence in cannabis vaping products from source to inhalation. Sci Rep, 1, 31939. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40883388


Salazar, M. R., Saini, L., Nguyen, T. B., Pinkerton, K. E., Madl, A. K., Cole, A. M. and Poulin, B. A. (2025). Elevated Toxic Element Emissions from Popular Disposable E‑Cigarettes: Sources, Life Cycle, and Health Risks. ACS Cent Sci, 8, 1345-1354. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40893954


Wang, X., Tian, Y., Li, X., Zhang, J., Liu, Y., Chen, H., Hou, H. and Hu, Q. (2025). Toxicity of Novel and Emerging Nicotine and Tobacco Products: A Review. Int J Toxicol, 1.09158E+16. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40939584


Chowdhury, S., Roy, S., Ferdous, T., Osibogun, O., Asfar, T., Bursac, Z. and Maziak, W. (2025). Menthol flavour enhances vaping experiences: a randomised crossover clinical trial. Tob Control. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40813093


Diamond, G. L. and Klotzbach, J. M. (2025). Contribution of e-cigarette use to renal cadmium burden. J Toxicol Environ Health A, Jan-20. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40531136


Sompa, S. I., Ji, J., Rahman, M., Sjogren, B., Upadhyay, S., Ganguly, K., Olin, A. C., Bergstrom, A. and Palmberg, L. (2025). Local and systemic effects in e-cigarette users compared to cigarette smokers, dual users, and non-smokers. Respir Res, 1, 207. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40468357


Zhu, Y., Wang, H., Sun, J., Liu, F., Guo, L., Zhang, Q., Mao, J., Tian, S., Fan, W. and Xie, J. (2025). Effects of flavor ingredient ethyl vanillin on nicotine pharmacokinetics and neurotransmitters release. Eur J Pharmacol, 177852. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40541599


Yuce, Y. and Can Eke, B. (2025). Investigation of some metal levels in people using electronic cigarettes and IQOS. Toxicol Mech Methods, Jan-16. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40369841


Manietta, L., Drake, W. and Jayawardene, W. (2025). Comparative Analysis of Inflammatory and Heavy Metal Biomarkers in Exclusive E-Cigarette Users, Combustible Tobacco Users, and Non-Users Aged 18-30: A Cross-Sectional NHANES Analysis. J Xenobiot, 2. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40278158


Besaratinia, A. (2025). Electronic Cigarette-Derived Metals: Exposure and Health Risks in Vapers. Chem Res Toxicol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40094421


Kaur, G., Lamb, T., Tjitropranoto, A. and Rahman, I. (2025). Single-cell transcriptomics identifies a dampened neutrophil function and accentuated T-cell cytotoxicity in tobacco flavored e-cigarette exposed mouse lungs. bioRxiv. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40027777


Yang, B. R. and Lee, S. M. (2025). Electronic cigarette use and heavy metal exposure: Evidence from the Korea National Health and Nutrition Examination Survey. Ann Epidemiol, 1-Aug. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39889940


He, X., Meister, M., Jeon, J., Shinde, A., Zhang, Q., Chepaitis, P., Black, M., Shannahan, J. and Wright, C. (2025). Multi-Omics Assessment of Puff Volume-Mediated Salivary Biomarkers of Metal Exposure and Oxidative Injury Associated with Electronic Nicotine Delivery Systems. Environ Health Perspect, 1, 17005. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39819025


Demirci Atik, M., Yilmaz, S. and Kilinc, O. (2024). Could E-Cigarettes be the Source of Lead Toxicity?. Thorac Res Pract, 1. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39660886


Wang, Y., Zhong, J., Jin, Z., Luo, A., Wu, Z., Jiang, X., Chen, J., Liu, P. and Li, M. (2024). Cigarette and e-cigarette reversely regulated autophagy via distinct level of ROS in vitro. Ecotoxicol Environ Saf, 117448. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39626481


Earlier news and research

For news items and research on this topic earlier than 2025, click here.

Intro
Chapter 2