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18.6.10 E-cigarette use and mental health
Foreword

Relevant news and research: E-cigarette use and mental health

Barakat, M., Alzaghari, L. F., Al-Najjar, M. A. A., Al-Zuhd, T., Abdaljaleel, M., Abu-Qatouseh, L., Thiab, S. and Alqudah, A. (2025). E-cigarette exposure and CDP choline modulate withdrawal- induced anxiety and hormonal levels in rats. Sci Rep, 1, 42715. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41315627


Hackworth, E. E., Vidana-Perez, D., O'Neal, R., Kim, M., Fillo, J., Hammond, D. and Thrasher, J. F. (2025). The Association Between Adolescent Mental Health Symptoms and Characteristics of Cigarette and E-Cigarette Use. Subst Use Misuse, 1-10. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41250305


Alotaibi, T. F. and Alqahtani, M. M. (2025). Depression or anxiety disorder moderates the relationship between smoking status and e-cigarette use status: a cross-sectional study. BMC Public Health, 1, 3663. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41163156


Mahdi, A., Alfadhli, L., Chadi, N., Etches, S., Ignaszewski, M. J., Panesar, B., Porath, A., Desclouds, P., Constantakis, S., Samaan, Z., Hatcher, S., Brouwers, M. and Rosic, T. (2025). Evaluating practices in the management of youth nicotine vaping in hospital-based child and youth mental health and addictions settings in Canada: protocol for a mixed-methods study. BMJ Open, 10, e109023. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41073122


Treur, J. L., Vermeulen, J. M. and van de Weijer, M. P. (2025). Editorial Perspective: Smoking, vaping and mental health - a perspective on potential causal mechanisms. J Child Psychol Psychiatry. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41028976


Bergman, M. (2025). Vapes on our drug charts. Br J Psychiatry, 1. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40947812


Richards, V. L., Oliver, J. A., Pan, S. J., Frank-Pearce, S. G., Smith, M. A., Nagawa, C. S. and Cohn, A. M. (2025). Mental health matters? An examination of how anxiety and depression influence the alcohol-e-cigarette use relationship. Addict Behav, 108504. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41021996


Ji, S., Chen, L., Zhuang, S., Wei, L., Gou, L., Shi, C., Jia, H. and Chen, X. (2025). Bidirectional Association Between E-Cigarette Use and Depression: A Meta-Analysis. Nicotine Tob Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40794808


VanFrank, B., Williams, T. R., Alcantara, I. C., Hertz, M., Al-Shawaf, M., Meyers, C. and West, A. (2025). E-Cigarette Use and Symptoms of Depression and Anxiety Among US Middle and High School Students. Prev Chronic Dis, E51. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40815093


Bonevski, B., Rich, J., Lubman, D. I., Segan, C., Baker, A., Borland, R., Oldmeadow, C., Gartner, C., Walker, N., Dunlop, A., Daglish, M., Bullen, C., Bauld, L., Jacka, D., Garfield, J. B. B., McCrohan, R., Guillaumier, A. and Manning, V. (2025). Nicotine e-cigarettes for smoking cessation following discharge from smoke-free inpatient alcohol and other drug withdrawal services: a pragmatic two-arm, single-blinded, parallel-group, randomised controlled trial. Lancet Public Health, 7, e568-e577. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40602856


Kale, D., Beard, E., Ding, Y., Pervin, J., Wu, Q., Arundel, C., Parrott, S., Galdas, P., Horspool, M., Hough, S., Russell, G., Ker, S., Ratschen, E. and Shahab, L. (2025). Offering e-cigarettes for smoking cessation and reduction in people with mental illness (ESCAPE): Protocol for a randomized controlled trial. Addiction. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40590411


Sheikhattari, P., Barsha, R. A. A., Egboluche, C. and Assari, S. (2025). Use of Electronic and Conventional Cigarettes and Self-Rated Mental Health in High School Students. Children (Basel), 7. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40723095


Streck, J. M. and Rigotti, N. A. (2025). E-cigarettes in people with substance use disorder. Lancet Public Health, 7, e542-e543. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40602851


Sweitzer, M. M., Lazzari, J., Lunsford-Avery, J., McClernon, F. J., Kollins, S. H., Perkins, K. A. and Engelhard, M. (2025). Effects of initial nicotine exposure on cognition and nicotine reinforcement among non-smoking young adults with and without attention deficit hyperactivity disorder. J Psychopharmacol, 7, 694-702. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40579996


Pratt, S. I., Ferron, J. C., Santos, M., Brunette, M. F., Bianco, C., Sargent, J. and Xie, H. (2025). Carcinogen reduction in a randomized controlled study comparing e-cigarette provision to assessment only among people with serious mental illness who smoke. Drug Alcohol Depend, 112740. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40505215


Rullo, L., Morosini, C., Losapio, L. M., Vivarelli, F., Paolini, M., Fairclough, L. C., Canistro, D., Romualdi, P. and Candeletti, S. (2025). Prolonged nicotine exposure, via electronic cigarette, selectively increases Bdnf/TrkB transcription, dynorphin peptide levels and OLIG2 in male rat VTA. Neuropharmacology, 110540. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40460907


Shukri, M., Sahib, F. H. and Conner, M. (2025). Vaping and Mental Health: Research Trends and Future Directions. Nicotine Tob Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40570198


Alwesmi, M. B., Hawamdeh, S., Alotaibi, S. F., Alfohaid, M. A., Alharbi, F. M., Alghamdi, N. A., Alghamdi, J. K., Aseeri, F. A., Alqhatani, R. A. and Saleh, A. (2025). Exploring the association between anhedonia and nicotine dependence: A study among female undergraduate students in Saudi Arabia. Tob Induc Dis. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40309026


Halladay, J., Visontay, R., Sunderland, M., Rowe, A. L., Smout, S., Devine, E., Stockings, E., Andrews, J. L., Champion, K. E., Gardner, L., Newton, N., Teesson, M. and Slade, T. (2025). Exploring a diverse set of specifications related to associations between adolescent smoking, vaping, and emotional problems: a multiverse analysis. Addict Behav, 108380. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40403400


Ibrahim, F. M., Shahrour, G., Hashim, A., Yasin, A. and Allam, A. R. (2025). E-cigarette usage and mental health among undergraduate medical and health sciences students. Sci Rep, 1, 13169. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40240761


Braillon, A. (2025). E-Cigarettes for smoking cessation in patients with opioid use disorders: From Charybdis to Scylla?. Nicotine Tob Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40059699


Dai, H. D. and Young, B. (2025). Changes in quality of life and mental health outcomes related to vaping cessation among US adults. Tob Control. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40147929


El-Shahawy, O., He, M., Korostoff-Larsson, O., Nahvi, S. and Palamar, J. J. (2025). E-cigarette use among a national sample of adults receiving substance use treatment in the United States. Addict Behav, 108314. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40086428


Erhabor, J., Yao, Z., Tasdighi, E., Shahawy, O. E., Benjamin, E. J., Bhatnagar, A. and Blaha, M. J. (2025). Association of e-cigarette use, psychological distress, and substance use: Insights from the All of Us Research Program. Addict Behav, 108322. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40112576


Nam, J. K., Yang, J. J., Ran, S., Piper, M. E. and Buu, A. (2025). Bidirectional relationships between sleep quality and nicotine vaping: studying young adult e-cigarette users in real time and real life. Nicotine Tob Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40043004


Pericot-Valverde, I., Nahvi, S., Heo, M., Gaalema, D. E., Thrasher, J. F., Batchelder, A. W. and Litwin, A. H. (2025). E-Cigarettes for smoking cessation in patients with opioid use disorders: From Charybdis to Scylla?- Authors Reply. Nicotine Tob Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40163717


Poudel, L., Baral, A., Abdshah, A., Grealis, K., Aka, A., Paudel, S. and Vidot, D. C. (2025). Sleep disturbances among young adult dual users of cigarettes and e-cigarettes: Analysis of the 2020 National Health Interview Survey. PLoS One, 3, e0320748. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40132026


Baggio, S., Bruggmann, P., Schoeni, A., Abolhassani, N., Tal, K., Pohle, S., Frei, A., Humair, J. P., Jacot-Sadowski, I., Vetsch, J., Lehner, L., Rihs, A., Getaz, L., Berthet, A., Haller, M., Stuber, M., Jakob, J. and Auer, R. (2025). Efficacy of e-cigarettes for smoking cessation in populations with psychiatric and/or substance use problems: A secondary analysis of a randomized controlled trial. Tob Prev Cessat. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39902147


Donal, Meilina, S. T., Ilahi, A., Nurbaiti, Pratama, A., Putri, R. D., Kuswidyanarko, A., Sagita, D. D. and Ramadhani, E. (2025). Clarifying the impact of E-cigarettes on mental health: What's next?. Gen Hosp Psychiatry, 107-108. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39919407


Liu, C. I., Chen, I. M., Wang, S. Y. and Chen, C. (2025). Emergence of a New Threat in East Asia: Severe Agitation and Suicide Attempts Linked to Etomidate-Infused E-Cigarettes. Asia Pac Psychiatry, 1, e70001. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39948057


Prayogi, F., Laras, P. B., Pribadi, H., Tanod, M. J. and Utomo, P. (2025). E-Cigarettes and Mental Health: A Critical Examination of Their Role in Smoking Cessation Programs. Gen Hosp Psychiatry, 35-36. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39985942


Richardson, M. K., Mattingly, D., Agbonlahor, O., McLeish, A., Hart, J. and Walker, K. (2025). Disparities in daily anxiety symptoms and current exclusive and dual cigarette and electronic vaping product use among US adults. J Stud Alcohol Drugs. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39913271


Echeveste Sanchez, M., Guerry, H., Grady, S. and Herman, M. (2024). Sex-Specific Effects in Acute Nicotine Vapor Exposure on Binge Drinking and Activity in the Central Amygdala and Ventral Tegmental Area. Nicotine Tob Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39749458


Garrett, B. A., Comiford, A. L., Dvorak, J. D., Ding, K., Rhoades, D. A., Wagener, T., Cole, A. B., Spicer, P. G. and Doescher, M. P. (2025). E-Cigarette Use and Depression Among American Indian Adults Who Smoke. J Racial Ethn Health Disparities. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39856447


Hackworth, E. E., Vidana-Perez, D., O'Neal, R., Kim, M., Fillo, J., Hammond, D. and Thrasher, J. F. (2025). Trends in Mental Health Symptoms, Nicotine Product Use, and their Association Over Time Among Adolescents in Canada, England, and the US: Findings from the ITC Adolescents Tobacco and Vaping Survey, 2020-2023. Nicotine Tob Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39820468


Rihs, A., Schoeni, A., Scharf, T., Jakob, J., Tal, K., Jacot-Sadowski, I., Humair, J. P., Frei, A., Brutsche, M., Rodondi, N., Auer, R. and Baggio, S. (2025). Effect of e-cigarettes for smoking cessation on depressive and anxiety symptoms: Secondary analysis of a randomized controlled trial. Gen Hosp Psychiatry, 67-72. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39827790


Earlier news and research

For news items and research on this topic earlier than 2025, click here.

Intro
Chapter 2