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18.6.4 E-cigarette use and the risk of cancer
Foreword

Relevant news and research: E-cigarette use and the risk of cancer

(2025). Urinary Carcinogen Concentrations in Electronic Cigarette Users Compared to Cigarette Smokers, Dual Users and Nonsmokers: Findings From the Path Study: Retraction. J Urol, 5, 558. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41065095


Kinney, R., Ponder, L., Patel, N., Chatterjee, A., Vu, K., Sidhu, H., Bikman, B., Reynolds, P. R. and Arroyo, J. A. (2025). Comparative Effects of Cigarette Smoke and E-Cigarette Vapor on Oral Squamous Cell Carcinoma: Unraveling Distinct Molecular Pathways. Dent Res Oral Health, 3, 97-103. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41048327


de Oliveira, G. G., Magalhaes Liberato, R. M. L., de Souza, A. T. B., Sarmento, A. C. A., de Moura Santos, E., de Medeiros, K. S. and Filho, I. A. (2025). Evidence on vaping e-cigarettes as a risk factor for cancer: A systematic review. J Cancer Policy, 100615. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40691942


Kopa-Stojak, P. N. and Pawliczak, R. (2025). Comparison of carcinogenic potential of alternative tobacco products. A systematic review. Toxicol Mech Methods, Jan-15. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40741827


Mevawalla, A., Khalil, M., Rashid, Z., Altaf, A., Sarfraz, A. and Pawlik, T. M. (2025). Cancer screening adherence among e-cigarette users in the United States. Tob Prev Cessat. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40717811


Camero, C., Pena, M. J., Bernal, C., Gonzalez, D., Bermudez, L. G., Pulido, Z., Padilla, D., Infante, A., Canas, A., Lopez-Kleine, L. and Rojas, A. (2025). Analysis of the transcriptional profile of mononuclear cells from e-cigarette users. Ecotoxicol Environ Saf, 118485. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40505275


Velasco, W. V., Grimaldo, M. T., Karimi, N., Clowers, M. J., Krishna, A., Wu, R., Ejaz, R., Yuan, B., Aguila, S. D., Bouchelkia, I., Barragan, J. E. M., Larsen, K. E., Rezai, Y., Khalaj, F., Mitra, K., Rodriguez, C. R., Millares, R., de Anda, A. B., Castro-Pando, S., Karandikar, U. C., Petrosino, J. F., McAllister, F., Kadara, H., Ostrin, E. J., Fahrmann, J. F., Hoffman, K. L. and Moghaddam, S. J. (2025). Comparative effects of combustible cigarette versus electronic cigarette exposures on KRAS mutant lung cancer promotion. Neoplasia, 101185. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40516145


Lee, P. N., Coombs, K. J. and Fry, J. S. (2025). Estimating lung cancer risk from e-cigarettes and heated tobacco products: applications of a tool based on biomarkers of exposure and of potential harm. Harm Reduct J, 1, 45. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40159472


Palaia, G., Mohsen, M., Pergolini, D., Bartone, V., Purrazzella, A., Romeo, U. and Polimeni, A. (2025). E-cigarette: a safe tool or a risk factor for oral cancer? A systematic review. J Clin Exp Dent, 2, e219-e228. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40092310


Perez-Leal, M., El Helou, B. and Roger, I. (2025). Electronic Cigarettes Versus Combustible Cigarettes in Oral Squamous Cell Cancer Patients: A Systematic Review. J Oral Pathol Med. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40043728


Zhang, X., Leng, J., Lv, L., Song, D. and Lv, X. (2025). Advances in the mechanistic understanding, biological consequences, and measurement of DNA adducts induced by tobacco smoke and e-cigarette aerosol: A review. Int J Biol Macromol, 141574. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40023427


Chhaya, D., Gress, M., Raja, A., Kosinska, W., Gordon, T., Zelikoff, J. and Guttenplan, J. B. (2024). Effects of E-Cigarette (e-cig) Aerosols on Mutagenesis in Selected Organs in a C57 lacI (BigBlue(TM)) Mouse Model. Int J Environ Res Public Health, 12. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39767534


Kundu, A., Sachdeva, K., Feore, A., Sanchez, S., Sutton, M., Seth, S., Schwartz, R. and Chaiton, M. (2025). Evidence update on the cancer risk of vaping e-cigarettes: A systematic review. Tob Induc Dis. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39877383


Li, D., Xie, Z., Shaikh, S. B. and Rahman, I. (2025). Altered expression profile of plasma exosomal microRNAs in exclusive electronic cigarette adult users. Sci Rep, 1, 2714. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39837838


Sayed, I. M., Chakraborty, A., Inouye, K., Dugan, L., Tocci, S., Advani, I., Park, K., Gaboyan, S., Kasaraneni, N., Ma, B., Hazra, T. K., Das, S. and Crotty Alexander, L. E. (2025). E-cigarettes increase the risk of adenoma formation in murine colorectal cancer model. Arch Toxicol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39786590


Alqutaibi, A. Y., Alharbi, A. T. and Alaydaa, R. M. (2024). Risks of E-cigarettes on oral health and increased susceptibility to oral cancer. J Taibah Univ Med Sci, 6, 1098-1099. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39703691


Earlier news and research

For news items and research on this topic earlier than 2025, click here.

Intro
Chapter 2