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18C.5 Health effects of oral nicotine products
Foreword

Relevant news and research: Health effects of oral nicotine products

Sharma, A., Nair, B. S. and Pemminati, S. (2025). 7-Hydroxymitragynine and Nicotine Pouch Withdrawal Syndrome: A Case Report. Cureus, 12, e98386. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41487756


Abid, S., Aggarwal, A., Duarte, F., Sethi, S., Iyengar, S. and Zarich, S. (2025). Nicotine pouches and youth: emerging patterns and potential cardiovascular risks. Front Public Health, 1632313. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41358246


Belcher, V., Haider, A., Crowder, K., McKenzie, M. and Woomer, H. (2025). An Unusual Suspect: Hyperprolactinemia From Nicotine Pouches. AACE Endocrinol Diabetes, 4, 246-248. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41467124


Nurkkala, J., Lampela, H., Sammalkorpi, H., Liisanantti, J., Kontinen, V. and Schramko, A. (2026). Consumption of Oral Nicotine Products in Relation to Postanesthesia Care Unit Recovery After Laparoscopic Appendectomy. A Prospective Study. Acta Anaesthesiol Scand, 1, e70163. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41355348


Zou, H., Lyu, Q. and Hu, S. (2025). Pathology of Oral Nicotine Pouches and Their Addiction Mechanisms. J Dent, 106272. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41319801


Alkhatib, O. A. (2025). Localized gingival recession and leukoplakia associated with nicotine pouch use: two clinical case reports. BMC Oral Health. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41310598


Chen, S., Lin, M. E., Maxim, T. and St John, M. A. (2025). Oral Nicotine Patches-Concerns for Otolaryngologists. JAMA Otolaryngol Head Neck Surg. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41129143


Dai, H. D. and Young, B. (2025). Biomarkers of Exposure to Tobacco-Related Toxicants among Adult Nicotine Pouch Users. Nicotine Tob Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40923918


Al-Nafisi, A. M., Alsulami, Z. B., Alsulami, M. B., Alhazmi, A. K., AlKhrashi, B. A., Alzakari, M. A., Alshutwi, A. S., Bokhari, K. Y., Alzkari, F. and Al-Ahmari, O. T. (2025). Assessing the gastrointestinal and psychological impacts of nicotine pouch use among adults in Saudi Arabia: A cross-sectional study. Tob Prev Cessat. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40831452


Anderer, S. (2025). Nicotine Pouch Ingestions Surge Among Young Children. JAMA. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40748532


Azzopardi, D., Brown, E., Meichanetzidis, F., Fiebelkorn, S., Haswell, L. E., Hardie, G. and McEwan, M. (2025). A Randomized Crossover Clinical Study to Assess the Effect of Oral Nicotine Pouches Used for Different Durations on Plasma Nicotine Pharmacokinetics in Healthy Oral Pouch Consumers. J Clin Pharmacol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40781988


Center for Tobacco Products (2025). FDA Urges Nicotine Pouch Manufacturers To Use Child-Resistant Packaging Following Increasing Reports of Accidental Exposure.  ,  ,  . Available from: https://www.fda.gov/news-events/press-announcements/fda-urges-nicotine-pouch-manufacturers-use-child-resistant-packaging-following-increasing-reports


Eversole, A., Imran, R., Gaitan, N., Cobb, C. O., Barnes, A. J., Halquist, M., Hayes, R. B., Lipato, T., Eissenberg, T. and Breland, A. (2025). Physiological and subjective effects of an oral nicotine pouch in people who use smokeless tobacco. Exp Clin Psychopharmacol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40839513


Keller-Hamilton, B., Curran, H., Atkinson, L., Suraapaneni, S., Hinton, A., Chrzan, K., Mays, D., El-Hellani, A., Wilson, C. W., Brinkman, M. C. and Wagener, T. L. (2025). Examining the role of freebase nicotine in the harm reduction potential of oral nicotine pouches versus moist snuff: A randomized crossover trial. Addiction. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40598715


Patterson, J. G., El-Hellani, A., Brinkman, M. C. and Keller-Hamilton, B. (2025). Oral Nicotine Pouch Misuse Popularized Online Raises Concerns. Nicotine Tob Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40580068


Polosa, R., Rodu, B. and Farsalinos, K. (2025). Health effects of e-cigarettes, heated tobacco, and oral nicotine products. Intern Emerg Med. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40679570


Axt, P. N., Mohr, T., Steffen, A., Plotze-Martin, K., Jagodzinski, N., Bohnet, S., Dromann, D., Bruchhage, K. L., Franzen, K. F. and Pries, R. (2025). Influence of Different Nicotine Sources on Exercise-Driven Immune Responses of Peripheral Blood Monocytes. Toxics, 6. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40559945


Elsokkary, E. M., Alsabhan, F. A., Alyahya, A. A., Alsahli, S. A., Almousa, A. M., Aldali, J. A. and Alasiri, G. (2025). Exploring the effect of nicotine pouches on users' health in Saudi Arabia: A cross-sectional study. Tob Induc Dis. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40352804


La Rosa, G. R. M., Fagerstrom, K., Pacino, S. A., Kowalski, J., Gorska, R., Gospodaru, S., Bordeniuc, G., Fala, V., Amaliya, A., Chapple, I. and Polosa, R. (2025). Self-reported oral health outcomes after switching to a novel nicotine pouch technology: a pilot study. Acta Odontol Scand, 292-298. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40422555


Salehi, A., Sarkar, M. A., Smith, J. H. and Rostami, A. A. (2025). Physiologically Based Pharmacokinetic Modeling to Predict Nicotine Pharmacokinetics of Nicotine Pouches Under Naturalistic Use Conditions. J Clin Pharmacol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40347000


Kamdar, D. (2025). Why nicotine pouches may not be the best choice to help you stop smoking. The Conversation. Available from: https://theconversation.com/why-nicotine-pouches-may-not-be-the-best-choice-to-help-you-to-stop-smoking-251856


Liu, J., Edmiston, J. S., Wang, J., Milleman, K. R., Milleman, J. L., Yoder, A. L., Gogova, M. and Sarkar, M. A. (2025). Oral Health Effects Among Adults Switching from Cigarettes to on!(R) Nicotine Pouches Compared to Those Who Continue Smoking. Oral Health Prev Dent, 189-201. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40130808


Wiener, R. C., Gaydos, M. S. and Bhandari, R. (2025). Nicotine Pouch Use and Adolescents' and Children's Grades in School, National Youth Tobacco Survey 2022-23. Subst Use Misuse, 1-Jul. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40108805


Dennison Himmelfarb, C. R., Benowitz, N. L., Blank, M. D., Bhatnagar, A., Chase, P. J., Davis, E. M., Fetterman, J. L., Keller-Hamilton, B., Ogungbe, O., Page, R. L., 2nd, Rezk-Hanna, M., Robertson, R. M., Whitsel, L. P. and American Heart Association Advocacy Coordinating, C. (2025). Impact of Smokeless Oral Nicotine Products on Cardiovascular Disease: Implications for Policy, Prevention, and Treatment: A Policy Statement From the American Heart Association. Circulation, 1, e1-e21. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39624904


Keyser, B. M., Leverette, R., McRae, R., Wertman, J., Shutsky, T., Szeliga, K., Makena, P. and Jordan, K. G. (2024). In vitro toxicological evaluation of pouched portioned oral nicotine products. Front Toxicol, 1452274. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39669663


Scherer, G., Pluym, N. and Scherer, M. (2024). Oral health risks in adults who use electronic nicotine delivery systems and oral nicotine pouches: a critical review of the literature and qualitative synthesis of the available evidence. Harm Reduct J, 1, 229. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39736680


Earlier news and research

For news items and research on this topic earlier than 2025, click here.

Intro
Chapter 2