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18B.5 Exposure to chemicals from heated tobacco products
Foreword

Relevant news and research: Exposure to chemicals from heated tobacco products

Mazaki, Y., Miwa, S., Shinkai, R. and Horinouchi, T. (2025). Effects of nicotine- and tar-free smoke extracts from combustible cigarettes and heated tobacco products on the function of neutrophil-like HL-60 cells. J Pharmacol Sci, 4, 322-326. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41241443


Nishihara, D., Yuki, D. and Minami, N. (2025). Comparison of profiles of biomarkers of potential harm among healthy adults who used heated tobacco products, smoked combustible cigarettes, or who had never smoked: a cross-sectional, observational study. Intern Emerg Med. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41296154


Rantasa, M., Majer, D. and Finsgar, M. (2025). A Review of Analytical Techniques for the Analysis of Oral Smokeless Products and Heated Tobacco Products. Crit Rev Anal Chem, 1-19. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41217039


Liu, X., Tayyarah, R., Chang, X., Gao, X. and Chen, L. (2025). Critical Appraisal of Animal Studies Assessing Risk of Heated Tobacco Products-A Systematic Review. Nicotine Tob Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41070821


Cui, P., Lu, L., Wang, Y., Hua, Q., Zhang, K., Gao, J., Zhang, M., Gao, Y. and Li, B. (2025). Stability Evaluation Method and Application of Puff-by-Puff Release of Aerosol Constituents in Heated Tobacco Materials and Products. ACS Omega, 33, 37702-37709. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40893221


Li, J., Cao, Y., Zhang, W., Cheng, Q., Zhou, Y., Cai, Z., Yu, J., Qi, D. and Wu, D. (2025). Ultra-trace analysis of polycyclic aromatic hydrocarbons in heated tobacco products based on large volume thermal injection-column internal evaporation concentration. J Chromatogr A, 466330. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40907425


Nishimoto-Kusunose, S., Inaba, Y., Bekki, K. and Ushiyama, A. (2025). Determination of reactive oxygen species in mainstream smoke from various heated tobacco products. Environ Health Prev Med, 66. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40887275


Wang, B., Xie, F., Chen, M., Shang, P., Pan, L., Cui, H., Qin, Y., Zhang, L., Guo, J., Zhang, X., Nie, C., Wang, X. and Liu, S. (2025). A simple derivatization and highly sensitive gas chromatography-mass spectrometry method for the determination of glycidol and 2-/3-monochloropropanediol in heated tobacco product aerosol. J Chromatogr A, 466310. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40865308


Sakalauskaite, S., Zdanavicius, L., Steinmiller, J. and Istomina, N. (2025). Exposure to Toxic Compounds Using Alternative Smoking Products: Analysis of Empirical Data. Int J Environ Res Public Health, 7. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40724077


Wilkinson, P. J., Clarke, A., Fearon, I. M. and Barry, R. (2025). Emissions from conventional and electronic waterpipes relative to cigarettes and a heated tobacco product. Sci Rep, 1, 14176. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40307321


Lee, T., Park, J., Kim, Y., Chen, W. H. and Kwon, E. E. (2025). Comparison of toxic pyrogenic compounds derived from conventional cigarettes and heated tobacco products. J Hazard Mater, 138357. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40273862


Noura, I., Suzuki, S., Gi, M., Fujioka, M., Matsue, T., Kakehashi, A. and Wanibuchi, H. (2025). Comparative analysis of the toxic effects on the mouse lung of 4 weeks exposure to the heated tobacco product Ploom TECH+ and 3R4F reference cigarettes. J Toxicol Pathol, 2, 147-154. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40190623


Hoshino, S., Noro, K. and Amagai, T. (2025). Quantification of Flavors, Volatile Organic Compounds, Tobacco Markers, and Tobacco-Specific Nitrosamines in Heated Tobacco Products and Their Mainstream Aerosol. Chem Res Toxicol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40111923


Li, X., Ding, Z., Jiang, X., Wang, H., Luo, Y., Chen, H., Pang, Y., Hou, H. and Hu, Q. (2025). Reinforcement and MAO-A inhibition in heated tobacco products: flavor and brand variations. Front Psychiatry, 1515519. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40041694


Hashizume, T., Yamamoto, H., Ito, H. and Otsu, Y. (2025). In vitro toxicological assessment of aerosols from indirectly heated tobacco products using a solvent-free extraction method. Food Chem Toxicol, 115333. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39984026


Wang, H. T., Wang, P. H., Chen, C. Y., Liu, T. Y. and Tsou, H. H. (2025). Comparison of carbonyls and tobacco-specific nitrosamines in aerosols of heated tobacco products and conventional cigarette smoke using both targeted and untargeted analytical methods. Regul Toxicol Pharmacol, 105786. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39954766


Kagemichi, N., Umemura, M., Ishikawa, S., Iida, Y., Takayasu, S., Nagasako, A., Nakakaji, R., Akimoto, T., Ohtake, M., Horinouchi, T., Yamamoto, T. and Ishikawa, Y. (2024). Cytotoxic effects of the cigarette smoke extract of heated tobacco products on human oral squamous cell carcinoma: the role of reactive oxygen species and CaMKK2. J Physiol Sci, 1, 35. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39843023


Jin, X., Meng, D., Fu, L., Zhao, Y., Zhang, Q., Zhang, Z., Yin, X., Shen, Q., Wang, S., Zhang, Y., Wang, L., Lei, P. and Li, B. (2024). Analysis of the key component puff-by-puff transport in special segments and aerosol for electrical heated tobacco product. Front Chem, 1477795. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39624499


Earlier news and research

For news items and research on this topic earlier than 2025, click here.

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