Ambildhok, K. A., Asawa, K. and Garcha, V. (2025). Assessing the Health Impacts of Heated Tobacco Products Compared to Traditional Tobacco Use: A Systematic Review of Current Evidence. Cureus, 10, e95166. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/41281023
Loffredo, L., Maggio, E., Bartimoccia, S., Magna, A., Tote, C. M., Bagnato, C., Cinicola, B. L., Armeli, F., Leonardo, A., D'Amico, A., Greco, E., Frati, G., Biondi-Zoccai, G., Spalice, A., Angeloni, A., Pignatelli, P., Violi, F., Zicari, A. M., Carnevale, R. and Smoking Prevention Study, G. (2025). Tobacco Smoke Exposure and Oxidative Stress: The Role of Circulating Lipopolysaccharides in Heated and Conventional Products. Antioxidants (Basel), 11. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/41300474
Mazaki, Y., Miwa, S., Shinkai, R. and Horinouchi, T. (2025). Effects of nicotine- and tar-free smoke extracts from combustible cigarettes and heated tobacco products on the function of neutrophil-like HL-60 cells. J Pharmacol Sci, 4, 322-326. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/41241443
Park, J. M., Seo, Y. S., Kim, J. H., Jin, W., Yeo, J. Y., Kim, J., Kim, M. S. and Lee, M. Y. (2025). Whole cigarette smoke condensates of heated tobacco products disrupt cell adhesion and induce anoikis in human bronchial epithelial cells. Arch Toxicol. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/41272179
Schiopu, P., Toc, D. A., Colosi, I. A., Costache, C., Panaitescu, P. S., Neculicioiu, V. S., Gorcea, C. M., Zagarin, T. I., Murarasu, A. R. and Todea, D. A. (2025). Comparative Effects of Cigarette Smoke and Heated Tobacco Product Aerosols on Biofilm Production by Respiratory Pathogens. Microorganisms, 11. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/41304145
Toyokura, E., Yamada, K., Asai, K., Tsutsumi, M., Ueda, T., Hirai, K., Furukawa, Y., Miyamoto, A., Nishimura, M., Sato, K., Watanabe, T., Tabuchi, T. and Kawaguchi, T. (2025). Dual use of combustible and heated tobacco products associates persistent symptoms with a history of COVID-19: a JASTIS 2023 cross‑sectional study. Sci Rep, 1, 38659. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/41238605
(2025). Expression of Concern: Critical Appraisal of Animal Studies Assessing Risk of Heated Tobacco Products-A Systematic Review. Nicotine Tob Res. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/41148000
Al-Zalabani, A. H. (2025). Advancing the Evidence on Heated Tobacco Products and Cardiovascular Risk. JAMA Netw Open, 10, e2537346. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/41085991
Davigo, M., Caiment, F., Verheijen, M., van Schooten, F. J., van Herwijnen, M., Mommers, A., Opperhuizen, A., Talhout, R. and Remels, A. H. V. (2025). Alterations in the transcriptome of human primary bronchial epithelial cells exposed to emissions from a heated tobacco product. Biochim Biophys Acta Gen Subj, 12, 130869. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/41076084
Hashimoto, H., Shimazaki, Y., Nonoyama, T., Kito, H., Segawa, N., Okai, M., Uchibori, N., Tomaru, S. and Kawahara, M. (2025). Associations among smoking status, including the use of cigarettes, electronic cigarettes, and heated cigarettes, periodontal condition, and tooth loss in employed Japanese adults: a cross-sectional study. BMC Oral Health, 1, 1590. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/41074047
Iwanaga, Y., Nakai, M., Miyamoto, Y., Hirano, T. and Fujiwara, H. (2025). Heated Tobacco Product Spread and Hospitalizations for Acute Coronary Syndrome in Japan. JAMA Netw Open, 10, e2537334. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/41085989
Miller-Holt, J., O'Connell, G., Bach, R., Charriere, M., Kanemaru, Y., Su, Z., Larroque, S. and Jacobson, K. (2025). Assessing the comparability of toxic emissions reduction from heated tobacco aerosols relative to cigarette smoke: a scientific approach to bridging datasets. Intern Emerg Med. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/41162691
Noguchi, S., Ishimaru, T., Yatera, K., Fujino, Y. and Tabuchi, T. (2025). Association between heated tobacco product use and worsening asthma symptoms: findings from a nationwide internet survey in Japan, 2023. Environ Health Prev Med, 77. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/41033986
Parigi, T. L., Nardone, O. M., Lisa, M., Massimino, L., Gabbiadini, R., Innocenti, T., Bertani, L., Del Gaudio, A., Florez, P., Bertin, L., Barberio, B., Hupe, M., Lopetuso, L., Allocca, M., D'Amico, F., Furfaro, F., Zilli, A., Fiorino, G., Ungaro, F., Castiglione, F., Savarino, E., Dragoni, G., Scaldaferri, F., Armuzzi, A., Peyrin-Biroulet, L., Jairath, V., Pizarro, T. T. and Danese, S. (2025). The impact of E-Cigarettes and Heat-Not-Burn Tobacco on Postoperative Recurrence of Crohn's Disease: A Multicenter International Study. Am J Gastroenterol. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/41134080
Acanfora, M. and Vassallo, A. (2025). Preliminary Evidence From an Original Study Suggests Combustion, Not Nicotine, Drives Risk and Complications of Graves' Orbitopathy. Cureus, 8, e91181. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40901217
Gallart-Mateu, D., Fuentes-Ferragud, E., Coscolla, C. and de la Guardia, M. (2025). Harm reduction of heated tobacco in outdoor spaces in place of burnt tobacco smoking. Anal Methods, 34, 6831-6839. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40824280
Lee, Y. S., Lim, D. H., Maitlo, H. A. and Kim, K. H. (2025). The smoking of heat-not-burn (HNB) cigarette products and its effects on indoor air quality. J Hazard Mater, 138790. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40803208
Yamazaki, T. (2025). Secondhand exposure to tobacco products in pregnancy. Hypertens Res. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40817403
Yasuda, J., Notomi, T., Horinouchi, T. and Nakamura, T. Y. (2025). Direct effects of cigarette smoke extract from heated tobacco products on cardiomyocyte: Comparison with combustible cigarettes. J Pharmacol Sci, 2, 94-104. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40866021
Zhou, P., Wu, T., Chai, Y., Huang, Y., Liu, K., Lu, Y., Liu, J. and Liang, K. (2025). Multiomics profiling reveals systemic biological responses to severe subacute exposure to heated tobacco products in rats. Sci Rep, 1, 28372. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40760008
Znyk, M. and Kaleta, D. (2025). The Health Effects of Heated Tobacco Product Use-A Narrative Review. Healthcare (Basel), 16. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40868658
Pavlov, N., Popova-Sotirova, I., Musurlieva, N., Raycheva, R., Trifonov, K., Atanasova, M. and Cholakova, R. (2025). Influence of Ordinary Cigarettes and Their Substitute IQOS((R)) on Secretory Immunoglobulin A in Unstimulated Saliva. Dent J (Basel), 7. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40710142
Polosa, R., Rodu, B. and Farsalinos, K. (2025). Health effects of e-cigarettes, heated tobacco, and oral nicotine products. Intern Emerg Med. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40679570
Swiatkowska, B., Jankowski, M. and Kaleta, D. (2025). Effects of Heated Tobacco Use on Blood Parameters and Cardiovascular Risk in Healthy Men. Med Sci Monit, e948556. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40653690
Davigo, M., Claudino Bastos, V., Mengels, K., Mommers, A., van Schooten, F. J., Briede, J. J., Jessen, P., Opperhuizen, A., Talhout, R., Langie, S. A. S. and Remels, A. H. V. (2025). Heated tobacco product emissions induce DNA damage in human bronchial epithelial cells via radical formation. Free Radic Res, Jan-17. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40548961
Iizuka, K., Iizuka, Y., Ito, S., Endo, T., Nukariya, H., Takeuchi, Y., Koike, T., Kurihara, K., Takahashi, H., Nakagawa, M., Hamada, T., Ohtake, S., Iriyama, N., Miura, K., Nakayama, T., Hatta, Y., Nakamura, H. and Komatsu, N. (2025). Introducing heat-not-burn tobacco improves hematocrit and cigarette smoking-related symptoms in patients with smokers' polycythemia and polycythemia vera. PLoS One, 5, e0323437. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40435128
Rasperini, G., Codari, M., Moiana, A., Tarantini, L., Bollati, V., Bellucci, G., Consonni, D., Larsson, L. and Asa'ad, F. (2025). DNA Methylation of iNOS, eNOS, TP53 and LINE-1 in Gingival Tissues of Cigarette Smokers, Heat-Not-Burn Smokers and Never Smokers: An Exploratory Study. Clin Exp Dent Res, 3, e70141. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40387376
Braznell, S., Dance, S., Hartmann-Boyce, J. and Gilmore, A. (2025). Impact of heated tobacco products on biomarkers of potential harm and adverse events: a systematic review and meta-analysis. Tob Control. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40300839
Doya, K., Imamura, K., Mori, S., Nakane-Koyachi, S., Kokubu, E., Ishihara, K. and Saito, A. (2025). Investigating the Effects of Heated Tobacco Products on Periodontal Healing: Insights From In Vivo and In Vitro Experiments. Cureus, 3, e80733. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40242708
Giallongo, S., Bellia, F., Russo, A., Fallico, M., Polosa, R., Castellino, N., Longo, A., Emma, R., Partsinevelos, K., Caruso, M., Kartasasmita, A. S., Sferrazzo, G., Barbagallo, I. A., Caltabiano, R., Broggi, G., Alanazi, A. M. and Li Volti, G. (2025). Comparative Evaluation of Cigarette Smoke and a Heated Tobacco Product on Corneal Oxidative Stress in an Air/Liquid Interface Model. Invest Ophthalmol Vis Sci, 4, 4. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40168152
Znyk, M., Raciborski, F. and Kaleta, D. (2025). Evaluation of Morphology and Biochemical Parameters of Young Adults Using Heated Tobacco Products in Poland: A Case-Control Study. J Clin Med, 8. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40283564
Ahmed, N. B., Salem, A. E., AbdulGawad, E. A., Ahmed, H. H. and Mohamed Abdel Gawad, M. H. (2025). Acute effects of heated tobacco smoking: a single-center study. Monaldi Arch Chest Dis. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40099401
Kim, D. H., Hong, S. W. and Park, N. (2025). Comparative analysis of alpha-fetoprotein, carbohydrate antigen 19-9, carcinoembryonic antigen, and prostate-specific antigen among conventional cigarette smokers, heated tobacco product users and quitters. Tob Induc Dis. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40078230
Lee, P. N., Coombs, K. J. and Fry, J. S. (2025). Estimating lung cancer risk from e-cigarettes and heated tobacco products: applications of a tool based on biomarkers of exposure and of potential harm. Harm Reduct J, 1, 45. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40159472
El Shafei, S. F., Amin, A. H., Abdelghaffar, E. G., Moataz, S., Makkeyah, F., Shamel, M. and Al Ankily, M. (2025). The effect of cigarette smoking and heated tobacco products on different denture materials; an in vitro study. BMC Oral Health, 1, 179. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/39894835
Fekih-Romdhane, F., Hallit, R., Malaeb, D., Sakr, F., Dabbous, M., Obeid, S. and Hallit, S. (2025). Is it about substituting an addiction with another? development and initial psychometric properties of the first heated tobacco products addiction questionnaire (HeaTPAQ). Addict Sci Clin Pract, 1, 20. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/40012081
Furnari, S., Emma, R., Caruso, M., Furneri, P. M. and Fuochi, V. (2025). Evaluating the Risks of Heated Tobacco Products: Toxicological Effects on Two Selected Respiratory Bacteria and Human Lung Cells. Toxics, 2. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/39997888
Kim, B. K., Yang, W. J., Seong, Y. S., Choi, Y. J., Park, H. J., Byun, M. K., Chang, Y. S., Cho, J. H. and Kim, C. Y. (2025). Comparative Assessment of Acute Pulmonary Effects Induced by Heat-Not-Burn Tobacco Aerosol Inhalation in a Murine Model. Int J Mol Sci, 3. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/39940903
Ooba, H., Maki, J., Tabuchi, T. and Masuyama, H. (2025). Relationship Between Heated Tobacco Products and Placental Abruption: A Prospective Cohort Study Using Online Questionnaire. J Epidemiol Glob Health, 1, 30. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/39976798
Ansari, S. M., Leroy, P., deLaBourdonnaye, G., Pouly, S., Reese, L. and Haziza, C. (2025). Differences in Biomarkers of Potential Harm After 2+ Years of Tobacco Heating System Use Compared to Cigarette Smoking: A Cross-Sectional Study. Biomarkers, Jan-22. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/39882959
Jee, Y., Shin, S. Y., Ryu, M. and Samet, J. M. (2024). The effect of heated tobacco products on metabolic syndrome: A cohort study. Tob Induc Dis. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/39687080
Kim, M., Lee, K. J., Choi, I., Kim, S. H. and Ryu, K. (2024). Relationship between Heated Tobacco Product Use and Low-Density Lipoprotein Cholesterol in Korean Adults: A Cross-Sectional Study Using Korea National Health and Nutrition Examination Survey 2018-2021 (VII-1 and VIII). Korean J Fam Med. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/39726248
Wang, X., Tian, Y., Chen, H., Hou, H. and Hu, Q. (2024). Airway organoids: 3D toxicology evaluation models in vitro of heated tobacco products for health risk. Toxicol In Vitro, 105995. Available from:
https://www.ncbi.nlm.nih.gov/pubmed/39667640