Home
3.23 Smoking, dementia and cognition
Foreword

Relevant news and research: Smoking, dementia and cognition

Dacey, R., Hou, L., Gurnani, A., Han, X., Paller-Moore, M. R., Chung, J., Durape, S., Rosenthaler, M., Uretsky, M., Abdolmohammadi, B., Lee, A. J., Brickman, A. M., Hohman, T. J., Cuccaro, M. L., Bennett, D. A., Crane, P. K., Kamboh, M. I., Kukull, W. A., Jun, G., Stein, T. D., McKee, A. C., Haines, J. L., Pericak-Vance, M. A., Wang, L. S., Schellenberg, G. D., Mayeux, R., Lunetta, K. L., Farrer, L. A. and Mez, J. (2025). Alzheimer's disease multi-ancestry genome-wide interaction and stratified study with smoking. Alzheimers Dement, 11, e70922. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41268768


Tong, Q., Wu, J., Jiao, Q., Wu, H., Gong, J. and Wu, Q. (2025). Global burden of Alzheimer's disease and other dementias attributable to smoking in 204 countries and territories, 1990-2021. PLoS One, 10, e0334619. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41091740


Wise, J. (2025). Stopping smoking even late in life is linked to slower cognitive decline, study finds. BMJ, r2168. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41093611


Australian Institute of Health and Welfare (2025). Dementia in Australia. . Available from: https://www.aihw.gov.au/reports/dementia/dementia-in-aus


Lee, B. and Kim, D. (2025). Comprehensive state smoke-free policies as a predictor of cognitive impairment among older Americans: the Health and Retirement Study. Tob Control. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40813094


Lv, Y., Xiang, Y., Fu, W., Li, B. and Li, X. (2025). Global burden trends of Alzheimer's disease and other dementias attributable to smoking from 1990 to 2021. J Alzheimers Dis, 1.38729E+16. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40770956


Zhao, J. V. (2025). Editorial: Unpacking the Link between Income, Smoking, and Dementia Risk: Insights and Opportunities. JMA J, 3, 777-778. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40786494


Chen, C., Zhu, S., Zheng, Z., Ding, X., Shi, W., Xia, T. and Gu, X. (2025). A Genome-wide study on the genetic and causal effects of smoking in neurodegeneration. J Transl Med, 1, 743. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40615926


Xu, H., Yang, L., Hu, S., Xu, X. and Yang, Y. (2025). An analysis of the global, regional, and national epidemiology and trends of Alzheimer's disease and other dementias linked to smoking from 1990 to 2021 and projections to 2050. Tob Induc Dis. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40735367


Dong, T., Zhang, S., Wang, H., Jiang, Y., Zhang, Q., Li, X. and He, L. (2025). Global, regional, and national disease burden of tobacco-related Alzheimer's disease among individuals over the age of 55: a global burden of disease study. Front Public Health, 1581871. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40438075


Li, R., Luo, L., Yuan, C. and Zhu, Q. (2025). Association of smoke exposure with cognitive function trajectories among middle and old-aged adults: evidence from the China Health and Retirement Longitudinal Study. J Glob Health, 4150. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40320800


Souza, I. N. O., Balerio, G. N., Pandy, V., Grilli, M. and Neves, G. A. (2025). Editorial: World No-Tobacco: effects of tobacco and nicotine on the brain. Front Pharmacol, 1610178. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40395725


Stuckwisch, R., Bennett, A., Rouanet, A., Edwards, L. J., Crowe, M., Judd, S. E. and Long, D. L. (2025). The association between smoking status and aging cognitive trajectory accounting for bias in attrition. Am J Epidemiol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40394218


Zhang, T., Luo, X., Zeng, Q., Li, K., Chen, Y., Sun, Y., Leng, L., Peng, G., Zhang, M., Liu, Z. and Alzheimer's Disease Neuroimaging, I. (2025). Smoking alters effective connectivity of resting-state brain networks in mild cognitive impairment. J Alzheimers Dis, 1.38729E+16. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40320779


Cheraghian, B., Rahimi, Z., Hashemi, S. J. and Torabipour, A. (2025). Association Between Smoking and Amnesia in Southwest Iran: A Population-Based Cross-sectional Study. J Res Health Sci, 2, e00647. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40259650


Cui, L., Wang, Z. H., Liu, Y. H., Ma, L. L., Qi, S. G., An, R., Chen, X., Guo, H. Y. and Yan, Y. X. (2025). Separate and Combained Associations of PM (2.5) Exposure and Smoking with Dementia and Cognitive Impairment. Biomed Environ Sci, 2, 194-205. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40159172


Fu, M., Wang, H., Ware, E. B. and Bakulski, K. M. (2025). Understanding causal estimates of smoking behaviors for cognitive impairment: A Mendelian randomization study. J Alzheimers Dis, 13872877251320562. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40025716


Gao, Y. L. and Xu, Q. H. (2025). No causal link between smoking and dementia with Lewy bodies. Parkinsonism Relat Disord, 107775. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40089453


Luan, X., Jin, Z., Xia, S., Li, J., An, Y., Gao, J., Wang, S., Xia, H., Pan, S., Zhang, Y., Song, W. and Wu, Y. (2025). Smoking impairs cognitive function through the mediating effect of periodontitis in older adults. BMC Psychiatry, 1, 292. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40148790


Mortensen, E. L., Hell, K., Okholm, G. T., Flensborg-Madsen, T. and Gronkjaer, M. (2025). The association between adult-life smoking and age-related cognitive decline in Danish men. PLoS One, 3, e0319839. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40106526


Zhang, C., An, Z., Jiang, J., Ge, J., Huang, W., Pei, J., Liu, Y., Yao, J., Guo, Z., Liu, X. and Cui, Y. (2025). Global, regional, and national burden of tobacco-related neurological disorders from 1990 to 2021: Trends and future projections. Tob Induc Dis. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40078231


Guo, Z., Xiao, Q., Li, T., Deng, Y., Liu, P., Ren, X., Xu, B., Chen, X., Huang, H., Qin, W., Huang, C., Luo, L., Liu, J. and Lu, S. (2025). Co-exposure to polycyclic aromatic hydrocarbons and nicotine and their associations with cognitive impairment risk in older adults from southern China. Food Chem Toxicol, 115255. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39828119


Lin, C., Lin, F., Yang, K., Zhong, Y., Luo, Y., Chen, H., Zhang, W., Chen, X., Ye, Q., Zeng, Y. and Cai, G. (2025). The brain structure underlying the nonlinear association between early-life tobacco smoke exposure and the risk for cognitive decline and dementia in adulthood: a large prospective cohort study. BMC Public Health, 1, 216. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39827101


Muhammad, F., Ummah, A. S., Aisyah, F., Danuaji, R., Mirawati, D. K., Subandi, S., Hamidi, B. L., Hutabarat, E. A. J., Reviono, R., Rahmawati, Y. E. N. and Ridwan, I. (2024). Active and Passive Smoking as Catalysts for Cognitive Impairment in Rural Indonesia: A Population-based Study. Oman Med J, 4, e655. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39790297


Proud, E. K., Rodriguez-Ruiz, M., Gummerson, D. M., Vanin, S., Hardy, D. B., Rushlow, W. J. and Laviolette, S. R. (2024). Chronic nicotine exposure induces molecular and transcriptomic endophenotypes associated with mood and anxiety disorders in a cerebral organoid neurodevelopmental model. Front Pharmacol, 1473213. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39764466


Qi, X., Zhang, R., Zhu, H., Luo, J., Zhang, Q., Wang, W., Wang, T. and Zhang, D. (2024). Dietary Iron Intake and Mental and Behavioral Disorders Due to Use of Tobacco: A UK Biobank Study. Nutrients, 1. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39796473


Zuo, W., Peng, J. and Wu, J. (2024). Relationship of smoking cessation duration and cognitive function among middle-aged and older adults in China: a national cross-sectional study. Front Public Health, 1503152. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39839407


Xie, Y., Yang, M., Wang, H., Chen, Y., Shi, X., Tang, H. and Sun, Q. (2025). Potential molecular mechanisms of tobacco smoke exposure in Alzheimer's disease. Brain Res, 149394. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39694170


Earlier news and research

For news items and research on this topic earlier than 2025, click here.

Intro
Chapter 2