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3.3 Smoking and cancer
Foreword

Relevant news and research: Smoking and cancer

Caturegli, G., Zhu, X., Palis, B., Mullett, T. W., Resio, B. J. and Boffa, D. J. (2025). Smoking Status of the US Cancer Population and a New Perspective From the National Cancer Database. JAMA Oncol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40146125


Jiang, Q., Junjun, L., Wang, X., Luo, L., He, G., Wu, X., Min, Q., Long, Y., Wenjun, W., Zhu, T. and Yao, Y. (2025). Beyond self-reports: serum cotinine reveals sex-and age-related differences of smoking on all-cause and disease-specific mortality. Front Public Health, 1512603. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40034165


Sharma, P., Jain, T., Sorgen, A., Iyer, S., Tarique, M., Roy, P., Kurtom, S., Sethi, V., Bava, E. P., Gutierrez-Garcia, A. K., Vaish, U., Suresh, D. S., Sahay, P., Edwards, D., Afghani, J., Putluri, S., Reddy, K. R. K., Amara, C. S., Kamal, A. H. M., Fodor, A. and Dudeja, V. (2025). Smoking-induced gut microbial dysbiosis mediates cancer progression through modulation of anti-tumor immune response. iScience, 3, 112002. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40104059


Tang, M. K., Ostlund, T., Dameh, N. F., Alcheva, A., Cohen, J. D., Hegeman, A. D., Carmella, S. G., Stepanov, I. and Hecht, S. S. (2025). Reactions of [13C]-Labelled Tobacco Smoke with DNA to Generate Selected Adducts Formed Without Metabolic Activation. Carcinogenesis. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40036216


Durfee, C., Bergstrom, E. N., Diaz-Gay, M., Zhou, Y., Temiz, N. A., Ibrahim, M. A., Nandi, S. P., Wang, Y., Liu, X., Steele, C. D., Proehl, J., Vogel, R. I., Argyris, P. P., Alexandrov, L. B. and Harris, R. S. (2025). Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis. bioRxiv. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39896515


Heilbrun, E. E., Tseitline, D., Wasserman, H., Kirshenbaum, A., Cohen, Y., Gordan, R. and Adar, S. (2025). The epigenetic landscape shapes smoking-induced mutagenesis by modulating DNA damage susceptibility and repair efficiency. Nucleic Acids Res, 4. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39970291


Zhu, S., Gao, J., Zhang, L., Dong, W., Shi, W., Guo, H., Zhang, X., Hua, T. and Yang, M. (2025). Global, regional, and national cardiovascular disease burden attributable to smoking from 1990 to 2021: Findings from the GBD 2021 Study. Tob Induc Dis. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39897459


John, U., Rumpf, H. J., Hanke, M. and Meyer, C. (2025). Estimating mortality attributable to alcohol or tobacco - a cohort study from Germany. Subst Abuse Treat Prev Policy, 1, 5. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39844184


Kang, H., Cheon, E., Hwang, J., Jo, S., Na, K., Park, S. Y. and Cho, S. I. (2025). Risk of all-cause mortality by various cigarette smoking indices: A longitudinal study using the Korea National Health Examination Baseline Cohort in South Korea. Tob Induc Dis. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39877382


Pinto, T. G., Avanci, L. D. S., Renno, A. C. M., Hipolide, D. C., Santos, J. N. D., Cury, P. R., Dedivitis, R. A. and Ribeiro, D. A. (2025). The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Induced by Cigarette Smoke in Humans: A Systematic Review. J Appl Toxicol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39825597


Singh, M., Dolan, C. V., Lapato, D. M., Hottenga, J. J., Pool, R., Verhulst, B., Boomsma, D. I., Breeze, C. E., de Geus, E. J. C., Hemani, G., Min, J. L., Peterson, R. E., Maes, H. H. M., van Dongen, J. and Neale, M. C. (2025). Unidirectional and bidirectional causation between smoking and blood DNA methylation: evidence from twin-based Mendelian randomisation. Eur J Epidemiol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39786687


Sullivan, S. M., Murphy, S. E., Stram, D. O., Wilkens, L. R., Haiman, C. A., Le Marchand, L., Stepanov, I. and Park, S. L. (2025). Genome-wide association study of urinary cadmium levels in current smokers from the multiethnic cohort study. Hum Mol Genet. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39820534


Australian Institute of Health and Welfare (2024). Australian Burden of Disease Study 2024. . Available from: https://www.aihw.gov.au/reports/burden-of-disease/australian-burden-of-disease-study-2024


Jackson, S. E., Jarvis, M. J. and West, R. (2024). The price of a cigarette: 20 minutes of life?. Addiction. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39734064


Earlier news and research

For news items and research on this topic earlier than 2025, click here.

Intro
Chapter 2