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3.3 Smoking and cancer
Foreword

Relevant news and research: Smoking and cancer

Chattopadhyay, D., Nitin, N., Jaggers, R. M., Athmanathan, B., Maremanda, K. P., Kanuri, B., Dahdah, A., Shukla, R., Lee, M. S., Murphy, A. J. and Nagareddy, P. R. (2025). Cigarette smoke aggravates atherosclerosis by promoting the infiltration of inflammasome-primed neutrophils and disrupting macrophage function in lesions. bioRxiv. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41278934


Feraldi, A., Sharma, S. and Giudici, C. (2025). Gender Gap in Cancer-Free Life Expectancy in the United States: The Association With Smoking, Poor Diet, and Physical Inactivity. J Aging Health, 8982643251404299. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41296508


Cheng, G., Luedtke, M. W., Wang, R., Yuan, J. M., Balbo, S. and Hecht, S. S. (2025). Quantitation by Liquid Chromatography-Nanoelectrospray Ionization-High Resolution Tandem Mass Spectrometry of Methyl and Ethyl DNA Adducts in Oral Cells from Cigarette Smokers and Nonsmokers of the Shanghai Cohort Study. Chem Res Toxicol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40934370


Gittens, O. E., Folger, A. T., Zhang, X., Ding, L., Parikh, N. A. and Mahabee-Gittens, E. M. (2025). Examination of DNA Methylation Patterns in Children Born Premature with Prenatal Tobacco Smoke Exposure. Toxics, 9. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41012410


Masdoumier, C., Broseus, L., Chuffart, F., Francois, O., Guilbert, A., Heude, B., Khochbin, S., Rousseaux, S., Seyve, E., Tafflet, M., Tost, J., Nakamura, A. and Lepeule, J. (2025). Immediate and durable effects of maternal tobacco consumption on placental DNA methylation: a replication and discovery study. Environ Epigenet, 1, dvaf016. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40927052


Pavlovic, D., Papic, D., Niciforovic, D. and Volarevic, V. (2025). Impact of cigarette smoke on the functions of mesenchymal stem cells. Cell Transplant, 9.6369E+15. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40974196


Simpkins, C. and Toska, E. (2025). Sparking malignancy: nicotine as a driver of stemness and metastasis in triple-negative breast cancer(dagger). J Pathol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40923665


Feng, X. and Huang, J. (2025). Temozolomide Resistance in Smoking-Related Bladder Cancer through TNFAIP6-Mediated Post-Translational Modifications. Arch Esp Urol, 6, 732-742. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40776873


Peris-Camarasa, B., Garrido, I. C., Pardo, O., Esteve-Turrillas, F. A., Dualde, P. and Coscolla, C. (2025). Smoking-induced increasing of oxidative stress in Spanish adults: A urinary biomonitoring study. Environ Toxicol Pharmacol, 104798. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40834991


Durfee, C., Bergstrom, E. N., Diaz-Gay, M., Zhou, Y., Temiz, N. A., Ibrahim, M. A., Nandi, S. P., Wang, Y., Liu, X., Steele, C. D., Proehl, J., Vogel, R. I., Argyris, P. P., Alexandrov, L. B. and Harris, R. S. (2025). Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis. Res Sq. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40502742


Dai, H. D., Hao, Y., Periera, M. and Michaud, T. (2025). Biomarkers of Exposure to Tobacco-Related Toxicants and Oxidative Stress among Cancer Survivors. Nicotine Tob Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40331779


Fang, Y. W., Chen, C. W., Su, T. C., Wang, C. and Lin, C. Y. (2025). Investigating the associations of blood lead and cadmium with smoking-related DNA methylation and mortality among U.S. adults. Ecotoxicol Environ Saf, 118360. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40409187


Chybowska, A. D., Bernabeu, E., Yousefi, P., Suderman, M., Hillary, R. F., Clark, R., MacGillivray, L., Murphy, L., Harris, S. E., Corley, J., Campbell, A., Spires-Jones, T. L., McCartney, D. L., Cox, S. R., Price, J. F., Evans, K. L. and Marioni, R. E. (2025). A blood- and brain-based EWAS of smoking. Nat Commun, 1, 3210. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40180905


Lehrer, S. and Rheinstein, P. (2025). Long-Lasting Cigarette Smoking Alterations in Immune Function Occur in Cannabis Smokers, Possibly Rendering Them Vulnerable to Smoking-Related Tumors in Later Life. Am J Clin Oncol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40266836


Caturegli, G., Zhu, X., Palis, B., Mullett, T. W., Resio, B. J. and Boffa, D. J. (2025). Smoking Status of the US Cancer Population and a New Perspective From the National Cancer Database. JAMA Oncol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40146125


Sharma, P., Jain, T., Sorgen, A., Iyer, S., Tarique, M., Roy, P., Kurtom, S., Sethi, V., Bava, E. P., Gutierrez-Garcia, A. K., Vaish, U., Suresh, D. S., Sahay, P., Edwards, D., Afghani, J., Putluri, S., Reddy, K. R. K., Amara, C. S., Kamal, A. H. M., Fodor, A. and Dudeja, V. (2025). Smoking-induced gut microbial dysbiosis mediates cancer progression through modulation of anti-tumor immune response. iScience, 3, 112002. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40104059


Tang, M. K., Ostlund, T., Dameh, N. F., Alcheva, A., Cohen, J. D., Hegeman, A. D., Carmella, S. G., Stepanov, I. and Hecht, S. S. (2025). Reactions of [13C]-Labelled Tobacco Smoke with DNA to Generate Selected Adducts Formed Without Metabolic Activation. Carcinogenesis. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40036216


Durfee, C., Bergstrom, E. N., Diaz-Gay, M., Zhou, Y., Temiz, N. A., Ibrahim, M. A., Nandi, S. P., Wang, Y., Liu, X., Steele, C. D., Proehl, J., Vogel, R. I., Argyris, P. P., Alexandrov, L. B. and Harris, R. S. (2025). Tobacco smoke carcinogens exacerbate APOBEC mutagenesis and carcinogenesis. bioRxiv. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39896515


Heilbrun, E. E., Tseitline, D., Wasserman, H., Kirshenbaum, A., Cohen, Y., Gordan, R. and Adar, S. (2025). The epigenetic landscape shapes smoking-induced mutagenesis by modulating DNA damage susceptibility and repair efficiency. Nucleic Acids Res, 4. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39970291


Pinto, T. G., Avanci, L. D. S., Renno, A. C. M., Hipolide, D. C., Santos, J. N. D., Cury, P. R., Dedivitis, R. A. and Ribeiro, D. A. (2025). The Impact of Genetic Polymorphisms on Genotoxicity (DNA Damage) Induced by Cigarette Smoke in Humans: A Systematic Review. J Appl Toxicol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39825597


Singh, M., Dolan, C. V., Lapato, D. M., Hottenga, J. J., Pool, R., Verhulst, B., Boomsma, D. I., Breeze, C. E., de Geus, E. J. C., Hemani, G., Min, J. L., Peterson, R. E., Maes, H. H. M., van Dongen, J. and Neale, M. C. (2025). Unidirectional and bidirectional causation between smoking and blood DNA methylation: evidence from twin-based Mendelian randomisation. Eur J Epidemiol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39786687


Sullivan, S. M., Murphy, S. E., Stram, D. O., Wilkens, L. R., Haiman, C. A., Le Marchand, L., Stepanov, I. and Park, S. L. (2025). Genome-wide association study of urinary cadmium levels in current smokers from the multiethnic cohort study. Hum Mol Genet. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39820534


Earlier news and research

For news items and research on this topic earlier than 2025, click here.

Intro
Chapter 2