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6.3 Mechanism of action
Foreword

Relevant news and research: Pharmacokinetics

Jiang, J., Li, X., Hu, A. F., Zhou, G. J., Gao, Y. H., Xu, C., Wu, X. M. and Wang, H. J. (2025). Nicotine and neuronal nicotinic acetylcholine receptors: unraveling the mechanisms of nicotine addiction. Front Neurosci, 1670883. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41179996


Li, M. D. (2025). Beyond the Smoke: The Enduring Imperative of Animal Models in Unraveling the Complexities of Nicotine Addiction. Nicotine Tob Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41206116


Leonard, M. Z., Elam, H. B., Yoon, H. J., Lago, S. H., Altemus, M. E., Roberts, S., Chevee, M. and Calipari, E. S. (2025). Nicotine enhances the ability of cues to control behavior and evoke dopamine release in the dorsolateral striatum. J Pharmacol Exp Ther, 9, 103662. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40812200


Buchwald, J., Lehtimaki, T., Raitakari, O., Salomaa, V., Kaprio, J. and Pirinen, M. (2025). A phenome-wide association study of genetically determined nicotine metabolism reveals novel links with health-related outcomes. Eur J Epidemiol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40646428


Ma, L., Tao, Q., Dang, J., Sun, J., Niu, X., Zhang, M., Kang, Y., Wang, W., Cheng, J. and Zhang, Y. (2025). The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis. Front Psychiatry, 1403604. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40291519


Okura, Y., Hallsten, M. N., Santis, G. D., Hirata, K., Fujii, M., Ishiuchi, S. I. and Xantheas, S. S. (2025). The Nicotine-Tryptophan Dimer: Probing the Principal Interaction of Nicotine with the Nicotinic Acetylcholine Receptor (nAChR), the Binding Pocket in the Human Brain. J Am Chem Soc, 17, 14043-14047. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40232364


Wang, A. Z., Jeon, J., Drenan, R. M. and Lester, H. A. (2025). Simulating early steps in nicotine dependence: Pharmacokinetics, activation, and chaperoning of nicotinic receptors. Mol Pharmacol, 4, 100016. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40215584


Iacino, M. C., Pitts, E. G., Bonsib, A. G., Sexton, L. L. and Ferris, M. J. (2025). Long-term effects of adolescent versus adult nicotine self-administration on cholinergic modulation of dopamine in the nucleus accumbens core. Drug Alcohol Depend, 112555. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39881470


Earlier news and research

For news items and research on this topic earlier than 2025, click here.

Intro
Chapter 2