Chapter 18 E-cigarettes and other alternative nicotine products

Relevant news and research: Chemicals in oral nicotine products

Yang, J., Guo, Y., Wang, Z., Wang, Y., Fu, D., Liu, Q., Solan, G. A., Ma, Y. and Sun, W. H. (2025). Manganese-Catalyzed Asymmetric Hydrogenation of Pyridyl Cyclic N-Alkyl Imines: A Direct Route to S-Nicotine and Derivatives. Org Lett, 11, 2564-2568. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40070246


Aldeek, F., Wagner, K., Haase, V., Sublette, E. and Lopez, V. (2025). Analysis and Toxicological Evaluation of Nicotine Degradants and Impurities in Oral Tobacco Products: A Case Study of on! PLUS Nicotine Pouches. ACS Omega, 6, 6267-6278. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39989796


Effah, F., Sun, Y., Friedman, A. and Rahman, I. (2025). Emerging nicotine analog 6-methyl nicotine increases reactive oxygen species in aerosols and cytotoxicity in human bronchial epithelial cells. Toxicol Lett, Sep-15. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39894318


Effah, F., Sun, Y., Lin, K. and Rahman, I. (2025). A comparative toxicological evaluation of emerging nicotine analogs 6-methyl nicotine and nicotinamide: a scoping review. Arch Toxicol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39937258


Sanchez, L. M., Leventhal, A. M., Unger, J. B. and Galimov, A. (2025). Expanding synthetic nicotine commercial market: Aroma King's 'NoNic' pouches and e-cigarettes. Tob Control. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39922702


Giovenco, D. P., Spillane, T. E., Lee, H. M., Ali, N., Little, R. M. P., Rahman, S. N. and Yagoda, S. S. (2025). Retail availability of oral nicotine pouches in 3 US cities: A geographic analysis. Nicotine Tob Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39756396


Jabba, S. V., Silinski, P., Yang, A. Y., Ouyang, W. and Jordt, S. E. (2024). Artificial Sweeteners in US-Marketed Oral Nicotine Pouch Products: Correlation with Nicotine Contents and Effects on Product Preference. Nicotine Tob Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39656927


Trotsko, N., Miroslaw, B., Jasinski, R., Dlugosz, M., Sadczuk, M. and Demchuk, O. M. (2024). Efficient Method of (S)-Nicotine Synthesis. Molecules, 23. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39683890


Vanhee, C., Dill, M., Canfyn, M., Tuenter, E. and Barhdadi, S. (2024). The Emergence of a Novel Synthetic Nicotine Analog 6-Methyl Nicotine (6-MN) in Proclaimed Tobacco- and Nicotine-Free Pouches Available in Europe. Drug Test Anal. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39697046


Zamarripa, C. A., Dowd, A. N., Elder, H. J., Czaplicki, L., Tfayli, D., Rastogi, K., Thrul, J., Strickland, J. C., Moran, M. B. and Spindle, T. R. (2024). A comprehensive review on oral nicotine pouches: Available scientific evidence and future research needs. Exp Clin Psychopharmacol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39621395


Earlier news and research

For news items and research on this topic earlier than 2025, click here.

Intro
Chapter 2