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3.12 Gastro-intestinal diseases
Foreword

Relevant news and research: Gastro-intestinal diseases

Balsiger, L., Himmelmann, A., Vavricka, S. R., Schreiner, P., Greuter, T., Scharl, M., Schoepfer, A. M., Rogler, G., Green, P. H. R., Zeitz, J. and Biederman, L. (2025). Disease course and symptoms in smoking versus non-smoking patients with Celiac disease. Acta Gastroenterol Belg, 4, 301-306. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41493317


Fantodji, C., Rousseau, M. C., Nicolau, B., Madathil, S., Benedetti, A. and Jantchou, P. (2026). Combined effects of smoking and hormonal contraceptives in the occurrence of inflammatory bowel disease - A weighted Cox analysis in a nested case-control study in Quebec, Canada. Prev Med, 108511. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41544942


Li, Q., Long, Y., Qin, Y., Zhang, L., Zeng, R., Luo, D., Li, Y., Chen, J., Zhu, Y., Feng, J., Ma, Y., Li, L., Zhang, H., Leung, F. W., Duan, C., Sha, W. and Chen, H. (2025). Early-life tobacco exposure, genetic susceptibility and multiple digestive diseases: evidence from two large cohorts and genetic analyses. Int J Surg. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41481893


Zhang, H., Zhao, J., Chen, J., Ma, X., Zhou, S., Noble, A., Kalla, R., Wellens, J., Liu, K., Theodoratou, E., Satsangi, J. and Li, X. (2026). Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages. Adv Sci (Weinh), e16704. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41521457


El-Azab, G., Elkhouly, E., Abouyoussef, R. and Nagdy, H. (2025). Smoking and liver diseases: an updated review of pathogenesis, progression, and therapeutic implications. Clin Exp Med, 1, 51. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41335258


Lu, H., Zhang, J., Wang, Z., Ni, J., Yang, S., Shi, Y., Chen, W., Zhu, S., Zhang, Z., Ni, Y., Nie, S. and Liu, L. (2026). Association of early-life tobacco smoke exposure with chronic gastrointestinal diseases in adulthood and trajectory of chronic gastrointestinal multi-morbidity: A large prospective cohort study. Public Health, 106085. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41344278


Qin, S., Xing, B., He, Y. and Liu, W. (2025). Impact of tobacco exposure on global deaths of digestive diseases: Findings from 1990-2021 and projected trends to 2042. Tob Induc Dis. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41340859


He, Y., Chen, J. and Li, T. (2025). Cigarette smoke-induced metabolic disorders potentially driven by inflammatory hub genes: Insights from network toxicology and molecular-docking. Comput Biol Chem, 108792. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41270548


Pan, K. T., Lin, F. M., Chu, T. W., Chen, M. T., Chuang, Y. C., Pei, D. and Shen, C. H. (2025). Effects of Sex, Smoking, and Physical Activity on Metabolic Syndrome Among Current Smokers: A Cross-Sectional Study from Taiwan. Healthcare (Basel), 21. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41228045


Agarwal, A. and Kedia, S. (2025). Up in Smoking-Can Smoking Cessation Reduce the Risk of Foregut Hemorrhage in Inpatients?. Dig Dis Sci. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41123790


Jin, J., Zhang, Y. and Huang, Y. (2025). The relationship between tobacco and non-alcoholic fatty liver disease incidence: a systematic review and meta-analysis of observational studies. Front Med (Lausanne), 1670932. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41169417


Bai, W., Zheng, Y., Pan, Y., Zhuang, M., Zhan, Y., Chen, W. and Liu, M. (2025). Sex-specific analyses of early-life tobacco smoke exposure and later-life irritable bowel syndrome: Sensitive window, mediation pathway, and genetic predisposition. Ecotoxicol Environ Saf, 119099. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40997561


Xi, W., Bai, X., Guo, T., Du, H., Zhang, Y., Cao, X., Jiang, Q., Feng, Y. and Yang, A. (2025). Smoking, alcohol consumption, and new-onset impaired glucose metabolism in male patients with type 1 autoimmune pancreatitis: a retrospective cohort study. Ther Adv Chronic Dis, 2.0462E+16. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40904426


Miyauchi, E., Taida, T., Uchiyama, K., Nakanishi, Y., Kato, T., Koido, S., Sasaki, N., Ohkusa, T., Sato, N. and Ohno, H. (2025). Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota. Gut. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40854688


Zhang, P., Zhu, J., Chen, X., Tao, C., Zhou, J., Zhang, Z. and Hong, X. (2025). Global, regional, and national burdens of non-alcoholic fatty liver disease attributable to smoking from 1990 to 2021. Ecotoxicol Environ Saf, 118818. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40768997


Kolec, R., Slaboszewski, M., Paszek, E., Baran, M. and Undas, A. (2025). Changes in circulating lipopolysaccharide and zonulin following acute myocardial infarction: The impact of smoking. Vascul Pharmacol, 107522. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40680807


Adeniran, E. A., Kim, S., Pandol, S. J., Yadav, D., Papachristou, G. I., Buxbaum, J. L., Pisegna, J. R. and Jeon, C. Y. (2025). Lifetime Smoking History and Marijuana co-use in Patients With Alcohol-related Acute Pancreatitis. Pancreas. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40549965


Alexander, D., Belal, M. and Alnounou, M. (2025). Smoking and the Bleeding Gut: Impact on 30-Day Readmission with Recurrent Non-variceal Upper GI Hemorrhage. Dig Dis Sci. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40461918


Joe, H., Oh, J. E., Cho, Y. J. and Shin, H. S. (2025). Association between smoking status and non-alcoholic fatty liver disease. PLoS One, 6, e0325305. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40489526


Liu, X., Lin, R., Li, X., He, M., Liu, Y., Hu, J., Chen, W., Li, Q., Yu, Y. and Zhou, P. (2025). Association of maternal smoking, breastfeeding, and multiple birth with irritable bowel syndrome in older adults: a UK Biobank cohort study. Gastroenterol Rep (Oxf), goaf042. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40502983


Shaham, D., Naveh, S., Zemel, M., Kariv, Y., Leibovitzh, H., Cohen, N. A., Thurm, T., Hirsch, A., Maharshak, N., Lahat, G. and Yuval, J. B. (2025). Smokers with Crohn's face worse surgical outcomes: A 90-day perioperative analysis. Am J Surg, 116458. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40499212


Li, C., Jiang, K., Pan, S., Tang, C. and Wang, K. (2025). A global perspective on smoking's impact on peptic ulcer disease: DALY trends and projections. Front Public Health, 1550045. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40365434


Li, Z., Guo, H., He, H., Wang, S., Pei, S. and Xie, L. (2025). The relationship between smoking cessation history and significant liver fibrosis among the population with metabolic dysfunction-associated steatotic liver disease in the United States. PLoS One, 4, e0320573. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40168280


Xue, F., Xue, J., Zhao, B. and Zhu, S. (2025). The Associations of Tobacco, Alcohol, and Coffee Consumption with Upper and Lower Gastrointestinal Disease Risk: A Mendelian Randomization Study. Gut Liver. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40211908


Yang, K., Lee, J., Han, J. W., Yang, H., Chae, S. Y., Chung, B. S. and Ryu, T. (2025). A comprehensive analysis of the impact of smoking on adverse clinical outcomes of steatotic liver diseases. Therap Adv Gastroenterol, 1.75628E+16. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40292092


Cui, G., Jiao, X., Wang, Z. and Zhang, Z. (2025). Association between tobacco smoke exposure and constipation among American adults: a National Health and Nutrition Examination Survey. Front Public Health, 1502341. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40109432


Lin, C. C., Li, C. I., Liu, C. S., Lin, C. H., Yang, S. Y. and Li, T. C. (2025). Relationship between tobacco smoking and metabolic syndrome: a Mendelian randomization analysis. BMC Endocr Disord, 1, 87. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40155847


Sahin, M. and Yuzugullu, D. (2025). Outcomes of metabolic syndrome and anxiety levels in light and heavy smokers. PeerJ, e19069. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40061234


Wang, S., Zhang, T., Li, D. and Cao, X. (2025). The global, regional and national burden of peptic ulcer disease attributable to smoking from 1990 to 2021: A population-based study. Prev Med Rep, 103019. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40092912


Lin, H. M., Zhang, J. R., Li, M. X., Hou, H., Wang, H. and Huang, Y. (2024). Cigarette smoking and alcohol-related liver disease. Liver Res, 4, 237-245. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39958918


Xu, J., Li, Y., Feng, Z. and Chen, H. (2025). Cigarette Smoke Contributes to the Progression of MASLD: From the Molecular Mechanisms to Therapy. Cells, 3. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39937012


Yang, D., Kim, Y. J. and Kim, J. W. (2025). Maternal smoking and its short- or long-term impact on offspring liver pathologies: a review of experimental and clinical studies. Toxicol Res, 2, 123-129. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40013082


Fan, J., Zeng, F., Zhong, H., Cai, J., Shen, W., Cheng, C., He, C., Liu, Y., Zhou, Y., Chen, S., Zhu, Y., Liu, T., Zheng, J. S., Wang, L., Chen, Y. M., Ma, W. and Zhou, D. (2025). Potential roles of cigarette smoking on gut microbiota profile among Chinese men. BMC Med, 1, 25. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39838369


Huang, X., Hao, X., Wang, T., Zhang, X., Wu, P., Shen, L., Yang, Y., Zhang, W. and Zhang, K. (2025). Sex-related association between smoke exposure and gallstones in a US population: a cross-sectional study. BMC Public Health, 1, 344. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39871261


Li, H., Shi, Q., Chen, C., Li, J. and Wang, K. (2024). Smoking-attributable peptic ulcer disease mortality worldwide: trends from 1990 to 2021 and projections to 2046 based on the global burden of disease study. Front Public Health, 1465452. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39741932


Mignini, I., Galasso, L., Piccirilli, G., Calvez, V., Termite, F., Esposto, G., Borriello, R., Miele, L., Ainora, M. E., Gasbarrini, A. and Zocco, M. A. (2024). Interplay of Oxidative Stress, Gut Microbiota, and Nicotine in Metabolic-Associated Steatotic Liver Disease (MASLD). Antioxidants (Basel), 12. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39765860


Wang, S., Zhang, T., Li, D. and Cao, X. (2025). Maternal Smoking Around Birth Is a Risk Factor for Gastrointestinal Diseases in Offspring: A Mendelian Randomization Study. Dig Dis Sci. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39843788


Imade, E. E. and Obayagbona, N. O. (2024). Impact of cigarette smoking on gut microbial dysbiosis: a structured literature review. Gut Microbiome (Camb), e13. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39703543


Moon, J. H. and Jung, S. (2024). Trend of Metabolic Syndrome Indicators in Working Korean Women According to Smoking Status and Workplace Size: A Population-Based Retrospective Longitudinal Study. Public Health Nurs. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39676030


Zhang, J., Hou, L., Lei, S., Li, Y. and Xu, G. (2024). The causal relationship of cigarette smoking to metabolic disease risk and the possible mediating role of gut microbiota. Ecotoxicol Environ Saf, 117522. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39709709


Zhu, Z., Wang, M., Guan, Y., Li, M., Peng, Q., Zheng, N. and Ma, W. (2024). Altered interaction network in the gut microbiota of current cigarette smokers. Eng Microbiol, 2, 100138. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39629322


Earlier news and research

For news items and research on this topic earlier than 2025, click here.

Intro
Chapter 2