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3.4 Lung cancer
Foreword

Relevant news and research: Lung cancer

Australian Institute of Health and Welfare (2025). Cancer data in Australia. . Available from: https://www.aihw.gov.au/reports/cancer/cancer-data-in-australia


Hu, S., Zhang, L., Ma, L., Yang, C., Ma, H., Tao, Y., Li, F., Hu, G. and Li, Q. (2025). Disease burden and changing trend of tracheal, bronchus, and lung cancer attributable to tobacco, globally and in China, the USA, the Russian Federation, and India, 1990-2021. J Thorac Dis, 9, 6581-6596. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41158393


Liu, L., Ren, Q., Zhang, Y., Yue, R., Mu, H., Li, Y., Li, H., Wang, Y., Li, H., Li, J., Li, C., Sun, W. and Pan, G. (2025). Incidence trends of different cancers attributable to smoking and alcohol consumption in Liaoning Province, Northeastern China from 2008 to 2019. BMC Public Health, 1, 3476. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41088074


Santiago-Perez, M. I., Guerra-Tort, C., Lopez-Vizcaino, E., Martin-Gisbert, L., Teijeiro, A., Garcia, G., Rey-Brandariz, J., Ruano-Ravina, A. and Perez-Rios, M. (2025). Lung cancer mortality attributable to smoking: a multi-scenario analysis with variable lag periods. Ann Epidemiol, 175-179. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41076151


Yan, S., Li, H., Liu, Y., Li, R., Liu, Y., Ma, L., Zhu, J., Zhang, Y. and Cheng, Y. (2025). The pathogenic mutations in smokers with non-small cell lung cancer: a next-generation sequencing study. Transl Lung Cancer Res, 9, 3659-3672. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41132982


Denic, L., Jagodic, J., Kozlica, K., Lukac, A., Ristanovic, A., Scancar, J. and Stojsavljevic, A. (2025). Comprehensive analysis of 44 elements in the lung cancer tissues of smokers: A comparative study with control lung tissues. J Trace Elem Med Biol, 127760. Available from: https://www.ncbi.nlm.nih.gov/pubmed/41004977


Lu, Y., Chen, H., Gan, J., Cai, J., Huang, C. and Chen, Q. (2025). Depression, smoking, and lung cancer vulnerability: Bridging mental-physical comorbidity through population-based evidence. Tob Induc Dis. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40936740


Dasari, K., Alfaro-Murillo, J. A. and Townsend, J. P. (2025). Tobacco smoke alters the trajectory of lung adenocarcinoma evolution via effects on somatic selection and epistasis. bioRxiv. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40777438


Druzhinin, V. G., Baranova, E. D., Demenkov, P. S., Matskova, L. V., Larionov, A. V. and Yuzhalin, A. E. (2025). Lower Respiratory Tract Microbiome Signatures of Health and Lung Cancer Across Different Smoking Statuses. Cancers (Basel), 16. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40867272


Jaylet, T., Chauhan, V., Mezquita, L., Boroumand, N., Laurent, O., Elihn, K., Lundholm, L., Armant, O. and Audouze, K. (2025). Comprehensive computational analysis via Adverse Outcome Pathways and Aggregate Exposure Pathways in exploring synergistic effects from radon and tobacco smoke on lung cancer. Front Public Health, 1571290. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40823246


Canale, M., Virga, A., Angeli, D., Fonzi, E., Gnetti, L., Dubini, A., Tedaldi, G., Urbini, M., Bocchialini, G., Petracci, E., Verlicchi, A., Cravero, P., Citarella, F., Bennati, C., Andrikou, K., Delmonte, A., Crino, L., Carbognani, P., Ulivi, P. and Ampollini, L. (2025). Genomic and Transcriptomic Profiles in Smokers and Never-Smokers Lung Squamous Cell Carcinoma Patients. Lung Cancer (Auckl), 85-96. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40612688


Clarke, A., Cunningham, A., Garcia-Alvarez, A., Spurgeon, L., Morgan, R., Carmona Alonso, A., Hernando, J., Capdevila, J., Backen, A., Campana, L. G., Manoharan, P., Verma, A., Lord, G. M., Chaturvedi, A., Mansoor, W. and Valpione, S. (2025). Smoking adversely affects survival of metastatic lung carcinoid patients: analysis of a large international audit and prognostic models for metastasis-free survival and overall survival. Neuroendocrinology, Jan-18. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40602391


Semprini, J. (2025). State Cigarette Taxes and Lung Cancer Incidence, United States, 1970-2019. Public Health Rep, 3.33549E+14. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40663168


Minervini, F., Lampridis, S., Kestenholz, P., Pardo, E., Crommelinck, J., Putora, P. M., Schnider, M., Petroncini, M., Mayer, N. and Bertoglio, P. (2025). The impact of smoking on lung cancer patients. Eur Respir Rev, 176. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40562437


Takada, I., Shimada, Y., Mimae, T., Kudo, Y., Nagashima, T., Miyata, Y., Ito, H., Okada, M. and Ikeda, N. (2025). Prognosis, imaging characteristics, and clinicopathological features of heavy smokers with clinical stage I lung adenocarcinoma: a multicenter study. Gen Thorac Cardiovasc Surg. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40493336


Nasrallah, N. A., Lee, B., Wiese, B. M., Karam, M. N., Mickler, E. A., Zhou, H., Paolelli, N., Stearman, R. S., Geraci, M. W. and Sears, C. R. (2025). Cigarette smoke and decreased DNA repair by Xeroderma Pigmentosum Group C use a double hit mechanism for epithelial cell lung carcinogenesis. Oncotarget, 396-409. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40391767


Sangani, R. G., Ghio, A. J., Deepak, V., Anwar, J., Vaidya, V., Patel, Z. and Abdullah, A. (2025). Impact of coal mine dust exposure and cigarette smoking on lung disease in Appalachian coalminers. Respir Res, 1, 184. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40369555


Wang, K., Li, J., Zhang, H., Ma, H., Cui, H. Y., Ju, H. Q., Zhang, J., Ma, Q. Z., Zhao, M., Zeng, Q. M., Zou, J., Sun, X. X., Nan, G., Qian, M., Jing, L., Li, Y., Xiong, C. F., Yang, Q. Z., Wang, H., Jiang, J. L., Chen, Z. N., Chen, L. and Huang, W. (2025). Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer Progression. Cancer Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40366632


de Andrade, D. P., Marques, C. M., de Andrade, D. C. R., Lenzi, L., Oliveira, C. S. and de Figueiredo, B. C. (2025). Trends in tobacco smoking and bladder and lung-bronchial cancer rates among non-hispanic white Americans (2000-2016). Arch Public Health, 1, 113. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40275317


Huang, H., Ding, C., Zhao, W. H., Zhang, H. B., Zhao, Z. X., Li, X. G., Wang, Y. J., Chen, P. J., Li, B. S., Li, X. B., Li, Y. W., Liu, H. Y. and Chen, J. (2025). Nicotine promotes the progression and metastasis of non-small cell lung cancer by modulating the OTUB1-c-Myc-EZH2 axis. Acta Pharmacol Sin. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40169782


Ma, H., Wang, G., Miao, S., Jin, C., Cai, J., Ge, W., Zhang, C., Zhang, E., Ma, H. and Zhu, M. (2025). Genetic Susceptibility to Lung Squamous Cell Carcinoma: New Insights on 9q33.2 Variants and Tobacco Smoking. Carcinogenesis. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40168134


Ruan, X., Wan, X., Ma, W., Liu, J., Tian, T., Zhang, J., Zhi, J., Qiu, M., Zhao, M., Wang, Q. and Li, P. (2025). Genome-wide screening and validation of exosome-derived TLN1 as a regulator of epithelial-mesenchymal transition in lung cancer. Sci Rep, 1, 11453. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40181045


Shaw, V. R., Byun, J., Han, Y. and Amos, C. I. (2025). Effects of smoking behavior on lung metastasis in the All of Us Research Program. Sci Rep, 1, 11114. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40169705


Zhang, Y., Wang, W., Dai, K., Huang, Y., Wang, R., He, D., He, J. and Liang, H. (2025). Global lung cancer burden attributable to air fine particulate matter and tobacco smoke exposure: spatiotemporal patterns, sociodemographic characteristics, and transnational inequalities from 1990 to 2021. BMC Public Health, 1, 1260. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40181341


Islami, F., Nargis, N., Liu, Q., Bandi, P., Siegel, R. L., Choudhury, P. P., Freedman, N. D., Warner, K. E. and Jemal, A. (2025). Averted lung cancer deaths due to reductions in cigarette smoking in the United States, 1970-2022. CA Cancer J Clin. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40131130


Korde, A., Ramaswamy, A., Anderson, S., Jin, L., Zhang, J. G., Hu, B., Velasco, W. V., Diao, L., Wang, J., Pisani, M. A., Sauler, M., Boffa, D. J., Puchalski, J. T., Yan, X., Moghaddam, S. J. and Takyar, S. S. (2025). Cigarette smoke induces angiogenic activation in the cancer field through dysregulation of an endothelial microRNA. Commun Biol, 1, 511. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40155749


Ouyang, C., Yu, X., Wang, H. and Zeng, P. (2025). Multidimensional bioinformatics perspective on smoking-linked driver genes and immune regulatory mechanisms in non-small cell lung cancer. J Transl Med, 1, 330. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40087674


Wang, R., Zhang, Z., Shan, X., Dong, J., Yang, X., Zhang, J. and Cao, J. (2025). Tobacco-related lung cancer burden in the Western Pacific Region from 1990 to 2021: An age-period-cohort analysis from the Global Burden of Disease Study. Tob Induc Dis. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40083560


Yamamoto, S., Koyanagi, Y. N., Iwashita, Y., Shinozaki, T., Fujiwara, Y., Sakakura, N., Hara, M., Nishida, Y., Otonari, J., Ikezaki, H., Tanoue, S., Koriyama, C., Kasugai, Y., Oze, I., Koyama, T., Tomida, S., Michihata, N., Nakamura, Y., Suzuki, S., Nakagawa-Senda, H., Nagayoshi, M., Kubo, Y., Kato, Y., Wakai, K., Watanabe, T., Ishizu, M., Takashima, N., Kadota, A., Momozawa, Y., Nakatochi, M., Tamura, T., Niimi, A., Ito, H. and Matsuo, K. (2025). Manuscript Smoking Behavior-related Genetic Variants and Lung Cancer Risk in Japanese: an Assessment by Mediation Analysis. Carcinogenesis. Available from: https://www.ncbi.nlm.nih.gov/pubmed/40059777


Deng, X., Zhang, H., Wang, Y., Ma, D. and Wu, Q. (2025). Exploring Potential Associations between Benzo[a]pyrene, Nicotine Exposure, and Lung Cancer: Molecular Insights, Prognostic Biomarkers, and Immune Cell Infiltration. Chem Res Toxicol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39980136


Leo, F., Migliaretti, G., Sobrero, S., Angelescu, D., Mc Bride, T., Dahan, M., Jougon, J. and Societe Francaise De Chirurgie Thoracique Et Cardiovasculaire, S. (2025). Impact of smoking habits on the postoperative outcome following lung surgery for cancer: results from the Epithor database. Eur J Cardiothorac Surg. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39977368


Burt, J. R., Qaqish, N., Stoddard, G., Jridi, A., Anderson, P. S., Woods, L., Newman, A., Carter, M. R., Ellessy, R., Chamberlin, J. and Kabakus, I. (2025). Non-small cell lung cancer in ever-smokers vs never-smokers. BMC Med, 1, 3. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39757150


Cayuela, L., Gaeta, A. M., Piury-Pinzon, J., Ortega-Calvo, M. and Cayuela, A. (2025). Changing Patterns of Lung Cancer Mortality in Andalusia: Insights From Age-period-cohort Analysis and Historical Smoking Trends. Open Respir Arch, 1, 100390. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39758958


Yamamoto, H., Shirasawa, M. and Naoki, K. (2025). Analysis of lung cancer incidence, mortality trends, and smoking rates in Japan:1975-2022 with insights on the impact of COVID-19. Int J Clin Oncol, 2, 199-209. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39821472


Aggarwal, R. K., Sidoli, S., Wang, J., Sahu, S., Sanawar, R., Gupta, V., Aluri, S., Sukrithan, V., Vegivinti, C. T. R., Zavras, P. D., Verma, D., Gordon-Mitchell, S., Agarwal, B., Verma, T., Starczynowski, D. T., Steidl, U. G., Shastri, A., Halmos, B., LaFave, L. M., Cheng, H., Verma, A. and Zou, Y. (2024). Smoking carcinogen induced inflammation promotes lung carcinogenesis via IRAK4 activation. Clin Cancer Res. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39704655


Chen, L., Wang, X., Xie, N., Zhang, Z., Xu, X., Xue, M., Yang, Y., Liu, L., Su, L., Bjaanaes, M., Karlsson, A., Planck, M., Staaf, J., Helland, A., Esteller, M., Christiani, D. C., Chen, F. and Zhang, R. (2024). A two-phase epigenome-wide four-way gene-smoking interaction study of overall survival for early-stage non-small cell lung cancer. Mol Oncol. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39630602


Zhang, J., Tang, J., Yang, R., Chen, S., Jian, H. and Zeng, P. (2024). The Global, Regional, and National Burden of Tracheal, Bronchus, and Lung Cancer Caused by Smoking: An Analysis Based on the Global Burden of Disease Study 2021. Ann Glob Health, 1, 77. Available from: https://www.ncbi.nlm.nih.gov/pubmed/39650717


Earlier news and research

For news items and research on this topic earlier than 2025, click here.

Intro
Chapter 2